G-Quadruplex DNA: Methods and Protocols (Methods in Molecular Biology #608) (Hardcover)

G-Quadruplex DNA: Methods and Protocols (Methods in Molecular Biology #608) Cover Image
By Peter Baumann (Editor)
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Description


Recent work has revealed that stabilizing G-quadruplexes in telomeric DNA inhibits telomerase activity, providing impetus for the development of G-quartet-interacting drugs, while G-quartet-containing oligonucleotides have been recognized as a potent class of aptamers effective against STAT3 and other transcription factors implicated in oncogenesis, proving these guanine-quartets to be a vital and rich area for future study. In "G-Quadruplex DNA: Methods and Protocols", experts in the field present a collection of detailed techniques for studying G-quartet formation, dynamics, and molecular recognition. Written in the highly successful Methods in Molecular Biology(TM) series format, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.

Authoritative and cutting-edge, "G-Quadruplex DNA: Methods and Protocols "promises to be a useful resource for those familiar with G-quartets as well as an easy entry point for those researchers from diverse fields who are just developing an interest in the exciting implications of G-quadruplex DNA.



Product Details
ISBN: 9781588299505
ISBN-10: 1588299503
Publisher: Humana
Publication Date: December 18th, 2009
Pages: 276
Language: English
Series: Methods in Molecular Biology